Tangential Flow Filtration: Challenges and Precision Pump Solutions

Technical Demands in Bioconcentration Processes

In tangential flow filtration (TFF) systems, peristaltic pumps operate synergistically with filtration modules to drive purification, concentration, and diafiltration processes. Pump selection critically influences operational efficacy and product integrity.

A DNA research laboratory conducting gold-conjugated antibody concentration encountered these challenges:

Biomolecule Preservation:

Maintain structural integrity and bioactivity during filtrate processing.

Dynamic Flow Regulation:

Initial flow rate: 40 mL/min, requiring progressive reduction during concentration (as solution viscosity increases) to prevent transmembrane pressure (TMP) exceeding filter tolerance limits (≤1.5 bar).

Continuous Operation Reliability:

Leak-free performance during 3–5 hour processing windows to minimize product loss.

LONGER’s Engineered TFF Solutions

Accurate Flow Control：

The flow error of the Longer Pump peristaltic pump is maintained within ±2%, and can be reduced to ±0.5% after calibration. This precise flow control ensures the achievement of the desired concentration effect.

High Reliability Design：

Longer Pump peristaltic pumps ensure that there will be no leakage during long-term continuous operation, reducing the loss of high-value biological molecules. The PharMed silicone hose provided by Longer Pump has excellent corrosion resistance and wear resistance, and the service life of the hose is greater than 10,000 hours, which greatly reduces the leakage loss caused by hose damage when transmitting high-value solutions.

Intelligent Flow Regulation：

Longer Pump peristaltic pump solution BT600-2J driver + YZ2515X pump head + PharMed 15# hose provides a wide flow range and can be adjusted manually or automatically to meet the concentration needs of different stages and maintain stable system pressure.

Low Shear Force Protection：

When Longer Pump peristaltic pumps pump biologically active substances, the low shear force design ensures the integrity and activity of biological molecules, meeting the laboratory's strict requirements for biological molecule protection.

Recommended Instrumentation

BT600-2J Mid-to-High-Flow Range Peristaltic Pump

YZII25 Peristaltic Pump Head

PharMed® BPT Tubing- Saint Gobain